Wednesday, January 30, 2013

iOS 6.1 jailbreak may arrive as soon as this Sunday

iOS 6.1 jailbreak may arrive as soon as this SundayThe long rumored jailbreak for iOS 6.1 may arrive as soon as this Sunday. The jailbreak which has been in testing for a while now has been working fine with each beta release of iOS 6.1. The team needed to wait for the official release of iOS 6.1 so it could be fully tested with the final version of the firmware. Well the good news is that after yesterday?s official release of iOS 6.1 all is working fine and we may even see the jailbreak released this Sunday.

MuscleNerd, who is part of the new jailbreak team which goes under the title of Evad3rs confirmed via Twitter that iOS 6.1 final version is safe and can be jailbroken by the same means as the other beta releases of the firmware. The even better news is that in a further tweet, MuscleNerd teased that the jailbreak may even arrive on Super Bowl Sunday.

@MikeBeas @evad3rs yep 6.1 is safe

Hey, did everyone know the Super Bowl is this Sunday? What will you be doing? /cc @evad3rs /evad3rs.com

This untethered jailbreak has been a long time coming but those of you that like to jailbreak your device should not have too much longer to wait now. A point to note however is that the Evd3rs team are advising those who want to jailbreak to avoid the OTA update method and instead connect your device to iTunes and do a full backup and update this way. Apparently doing an over the air update is more time consuming for the team to fully test and also provides different SHSH blobs.

For me, Sunday can?t come soon enough! The lines are blurring between a stock iPhone and a jailbroken one but the thought of getting back the extra functionality that BiteSMS and LockInfo provide is just too mouth-watering. Who else is looking forward to the iOS 6.1 jailbreak?

Source: Twitter 1,2, 3



Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/0ug40UfOZF8/story01.htm

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Police push for background checks on gun purchases

WASHINGTON (AP) ? Law enforcement leaders who met with President Barack Obama Monday urged him to focus on strengthening gun purchase background checks and mental health systems, but did not unify behind his more controversial gun control efforts.

The message from sheriffs and police chiefs gathered at the White House reflected the political reality in Congress that the assault weapons ban in particular is likely to have a hard time winning broad support. The president appeared to recognize the challenge of getting everything he wants from Congress as well, participants in the meeting said.

"We're very supportive of the assault weapons ban," as police chiefs, said Montgomery County, Md., Police Chief J. Thomas Manger in an interview with The Associated Press. "But I think everybody understands that may be a real tough battle to win. And one of the things that the president did say is that we can't look at it like we have to get all of these things or we haven't won."

Opinions over an assault weapons ban and limits on high capacity magazines ? two measures the president supports ? were divided in the room. While Manger said the police chiefs from the large cities support that kind of gun control, some of the elected sheriffs who were in the meeting may not.

"I think what was made clear was that gun control in itself is not the salvation to this issue," said Sheriff Paul Fitzgerald of Story County, Iowa, one of 13 law enforcement leaders who met with the president, vice president and Cabinet members for more than an hour, seated around a conference table in the Roosevelt Room.

Among the participants included three chiefs that responded to the worst shootings of 2012, including Aurora, Colo., where 12 were killed in July; Oak Creek, Wis., where six died in an assault on a Sikh temple, and Newtown, Conn., scene of the most recent mass tragedy that left 20 first-graders dead.

The White House recognizes that police are a credible and important voice in the debate over guns that has developed following last month's elementary school shooting in Connecticut. Obama opened the meeting before media cameras and declared no group more important to listen to in the debate.

"Hopefully if law enforcement officials who are dealing with this stuff every single day can come to some basic consensus in terms of steps that we need to take, Congress is going to be paying attention to them, and we'll be able to make progress," Obama said.

Obama urged Congress to pass an assault weapons ban, limit high capacity magazines and require universal background checks for would-be gun owners in a brief statement to the reporters. But participants said after the media was escorted from the room, the focus was not on the assault weapons ban.

"He did not ask us if we do or do not support an assault weapons ban," said Hennepin County, Minn., Sheriff Richard Stanek, president of the Major County Sheriffs' Association. "He did not ask us if we do or do not support high capacity magazines."

"I told him very candidly that this isn't just about gun control alone," Stanek said. He said the bigger issue is that the Justice Department's system for background checks is incomplete since many states don't report mental health data or felony convictions. He mentioned how in his home state of Minnesota, a 14-year-old shot and killed his mother with a shot gun, but was later able legally to buy additional handguns and automatic weapons because the background check did not reveal his history. "There's example after example after example like that across the country," Stanek said.

Fitzgerald said the mental health system needs to be better funded because jails across the country are becoming "dumping grounds for the mentally ill."

"I was not the only sheriff that spoke up on that issue," Fitzgerald said. "To me, that is the No. 1 thing if we are going to impact that kind of violence that's happening in America."

All the law enforcement participants interviewed said they appreciated the president's attention to the issue and found the meeting constructive. Manger said the president did a lot more listening than talking and heard about the need to fund more police officers to protect school safety and a proposal to restrict the sale of ammunition on the Internet besides the broad calls for stronger mental health and background check systems.

Philadelphia Police Commissioner Charles Ramsey, president of the Major Cities Chiefs Association, said he's never been more encouraged about the prospect of gun control legislation of some sort, even if the assault weapons ban his group supports is an uphill battle.

"You're not going to get 100 percent of people to agree on anything as it relates to gun control, and we're no different, but a majority of people in the room recognize that something needs to be done," he said. "This was not just a passing thing as far as the president and vice president are concerned. This is something that they are determined to keep in front of the American people until they get something passed."

While the assault weapons ban was not a major focus of the White House meeting, participants say it was discussed at length at a later meeting with Sen. Dianne Feinstein, D-Calif., who sponsored a ban in 1994 that lasted for a decade and last week introduced a renewal of the ban in Congress.

"I would say her message was not well received overall by the group," Stanek said. "Everyone has an opinion on it one way or another."

___

Follow Nedra Pickler on Twitter at http://twitter.com/nedrapickler

Source: http://news.yahoo.com/police-push-background-checks-gun-purchases-023655912--politics.html

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Tournament of THG Couples: Barack & Michelle Obama vs. Miley Cyrus & Liam Hemsworth!

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Friday, January 25, 2013

T-Mobile Offering Unified Communications to Biz Customers ...

T-Mobile USA today announced two new programs it hopes will entice businesses to use its network. The first is a unified communications platform that allows companies to integrate their office and mobile phone systems. T-Mobile Office Connect provides a single phone number for both the desktop and mobile devices, as well as one voicemail inbox f?
Phone Scoop ? Latest News

Source: http://www.gadget-rumours.com/cellphone/t-mobile-offering-unified-communications-to-biz-customers/

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Top Hiking, Climbing, and Camping Tech for 2013

Price: TBD

Why It's Cool: The brand with the three stripes acquired Five.Ten, a climbing and cycling-shoe label, about a year ago. That deal is now paying dividends with this new approach shoe, which uses Five.Ten's sticky outsole rubber?a proprietary material called Stealth, which flat-pedal mountain bikers discovered a few years back and climbers have flocked to for decades because it is exceptionally grippy and wears quite well. The Adidas Terrex Solo is meant for light hikers who really need extra traction for rock scrambles; should help Stealth reach a wider audience.

Available: Summer 2013

Source: http://www.popularmechanics.com/outdoors/recreation/top-hiking-biking-camping-tech-for-2013?src=rss

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Will seven of Oscar's nine best picture nominees cross the $100 million mark domestically?

LOS ANGELES (TheWrap.com) - Should "Zero Dark Thirty" and "Silver Linings Playbook" hit $100 million at the domestic box office - and both have an outside shot - it will mean an astonishing seven movies nominated this year for the Best Picture Oscar will have achieved that feat.

Fox's "Life of Pi" on Monday joined four other Best Picture Oscar nominees in surpassing the $100 million standard at the domestic box office. "Lincoln" ($161 million), "Django Unchained ($139 million), "Les Mis?rables: ($131 million) and "Argo" ($115 million) already have done it and are all still in theaters.

And the number for "Pi" should get an asterisk; it's made nearly four times that much - $392 million - at the overseas box office.

That's quite a change from last year, when only one of the nine nominated films - "The Help" - was over $100 million by the night of the Academy Awards.

Both "Zero Dark Thirty" and "Silver Linings" are at about $60 million with a month to go before the February 24 Oscars, so it will take some breaks to get to the magic number.

"They'll both inch their way into that range," BoxOffice.com vice president and senior analyst Phil Contrino told TheWrap Wednesday. "Neither is a sure bet, but both have momentum and could do it."

"'Zero Dark Thirty' probably has the better chance, because of the controversy surrounding it, but 'Silver Linings Playbook' is a crowd-pleaser and built to last, kind of like 'The Descendants' last year." That family drama also was nominated for Best Picture and wound up with $82 million domestically.

Five nominated films hit the $100 million mark in both 2010 and 2009, the first year the Academy expanded the number of Best Picture nomination slots from five to 10. In 2010, it was "Toy Story 3," "Inception," "True Grit," "The King's Speech" and "Black Swan." In 2009, it was "Avatar," "Up," "The Blind Side" "Inglourious Basterds" and "District 9."

Of course, box-office success doesn't generally translate into Oscar success. In the past 10 years, "The Departed" in 2006 and "Lord of the Rings: Return of the King" in 2003 were the only winners that came in as the highest-grossing films.

Source: http://news.yahoo.com/seven-oscars-nine-best-picture-nominees-cross-100-225102870.html

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How Much Will Tar Sands Oil Add to Global Warming?

tar-sandsTAR SANDS: At least 170 billion barrels of oil could be extracted from Alberta's oil sands deposits with today's technology. Image: ? David Biello

James Hansen has been publicly speaking about climate change since 1988. The NASA climatologist testified to Congress that year and he's been testifying ever since to crowds large and small, most recently to a small gathering of religious leaders outside the White House last week. The grandfatherly scientist has the long face of a man used to seeing bad news in the numbers and speaks with the thick, even cadence of the northern Midwest, where he grew up, a trait that also helps ensure that his sometimes convoluted science gets across.

This cautious man has also been arrested multiple times.

His acts of civil disobedience started in 2009, and he was first arrested in 2011 for protesting the development of Canada's tar sands and, especially, the Keystone XL pipeline proposal that would serve to open the spigot for such oil even wider. "To avoid passing tipping points, such as initiation of the collapse of the West Antarctic Ice Sheet, we need to limit the climate forcing severely. It's still possible to do that, if we phase down carbon emissions rapidly, but that means moving expeditiously to clean energies of the future," he explains. "Moving to tar sands, one of the dirtiest, most carbon-intensive fuels on the planet, is a step in exactly the opposite direction, indicating either that governments don't understand the situation or that they just don't give a damn."

He adds: "People who care should draw the line."

Hansen is not alone in caring. In addition to a groundswell of opposition to the 2,700-kilometer-long Keystone pipeline, 17 of his fellow climate scientists joined him in signing a letter urging Pres. Barack Obama to reject the project last week. Simply put, building the pipeline?and enabling more tar sands production?runs "counter to both national and planetary interests," the researchers wrote. "The year of review that you asked for on the project made it clear exactly how pressing the climate issue really is." Obama seemed to agree in his second inaugural address this week, noting "we will respond to the threat of climate change, knowing that the failure to do so would betray our children and future generations."

At the same time, the U.S. imports nearly nine million barrels of oil per day and burns nearly a billion metric tons of coal annually. China's coal burning is even larger and continues to grow by leaps and bounds. Partially as a result, global emissions of greenhouse gases continue to grow by leaps and bounds too?and China is one alternative customer eager for the oil from Canada's tar sands. Neither developed nor developing nations will break the fossil-fuel addiction overnight, and there are still more than a billion people who would benefit from more fossil-fuel burning to help lift them out of energy poverty. The question lurking behind the fight in North America over Keystone, the tar sands and climate change generally is: How much of the planet's remaining fossil fuels can we burn?

The trillion-tonne question
To begin to estimate how much fossil fuels can be burned, one has to begin with a guess about how sensitive the global climate really is to additional carbon dioxide. If you think the climate is vulnerable to even small changes in concentrations of greenhouse gases?as Hansen and others do?then we have already gone too far. Global concentrations of greenhouse gases in the atmosphere have reached 394 parts per million, up from 280 ppm before the Industrial Revolution and the highest levels seen in at least 800,000 years. Hansen's math suggests 350 ppm would be a safer level, given that with less than a degree Celsius of warming from present greenhouse gas concentrations, the world is already losing ice at an alarming rate, among other faster-than-expected climate changes.

International governments have determined that 450 ppm is a number more to their liking, which, it is argued, will keep the globe's average temperatures from warming more than 2 degrees C. Regardless, the world is presently on track to achieve concentrations well above that number. Scientists since chemist Svante Arrhenius of Sweden in 1896 have noted that reaching concentrations of roughly 560 ppm would likely result in a world with average temperatures roughly 3 degrees C warmer?and subsequent estimates continue to bear his laborious, hand-written calculations out. Of course, rolling back greenhouse gas concentrations to Hansen's preferred 350 ppm?or any other number for that matter?is a profoundly unnatural idea. Stasis is not often found in the natural world.

Concentrations of greenhouse gases in the atmosphere may not be the best metric for combating climate change anyway. "What matters is our total emission rate," notes climate modeler Ken Caldeira of the Carnegie Institution for Science Department of Global Ecology at Stanford University, another signee of the anti-Keystone letter. "From the perspective of the climate system, a CO2 molecule is a CO2 molecule and it doesn't matter if it came from coal versus natural gas."

Physicist Myles Allen of the University of Oxford in England and colleagues estimated that the world could afford to put one trillion metric tons of carbon into the atmosphere by 2050 to have any chance of restraining global warming below 2 degrees C. To date, fossil fuel burning, deforestation and other actions have put nearly 570 billion metric tons of carbon in the atmosphere?and Allen estimates the trillionth metric ton of carbon will be emitted around the summer of 2041 at present rates. "Tons of carbon is fundamental," adds Hansen, who has argued that burning all available fossil fuels would result in global warming of more than 10 degrees C. "It does not matter much how fast you burn it."

Alberta's oil sands represent a significant tonnage of carbon. With today's technology there are roughly 170 billion barrels of oil to be recovered in the tar sands, and an additional 1.63 trillion barrels worth underground if every last bit of bitumen could be separated from sand. "The amount of CO2 locked up in Alberta tar sands is enormous," notes mechanical engineer John Abraham of the University of Saint Thomas in Minnesota, another signer of the Keystone protest letter from scientists. "If we burn all the tar sand oil, the temperature rise, just from burning that tar sand, will be half of what we've already seen"?an estimated additional nearly 0.4 degree C from Alberta alone.

As it stands, the oil sands industry has greenhouse gas emissions greater than New Zealand and Kenya?combined. If all the bitumen in those sands could be burned, another 240 billion metric tons of carbon would be added to the atmosphere and, even if just the oil sands recoverable with today's technology get burned, 22 billion metric tons of carbon would reach the sky. And reserves usually expand over time as technology develops, otherwise the world would have run out of recoverable oil long ago.

The greenhouse gas emissions of mining and upgrading tar sands is roughly 79 kilograms per barrel of oil presently, whereas melting out the bitumen in place requires burning a lot of natural gas?boosting emissions to more than 116 kilograms per barrel, according to oil industry consultants IHS Cambridge Energy Research Associates. All told, producing and processing tar sands oil results in roughly 14 percent more greenhouse gas emissions than the average oil used in the U.S. And greenhouse gas emissions per barrel have stopped improving and started increasing slightly, thanks to increasing development of greenhouse gas?intensive melting-in-place projects. "Emissions have doubled since 1990 and will double again by 2020," says Jennifer Grant, director of oil sands research at environmental group Pembina Institute in Canada.

Just one mine expansion, Shell's Jackpine mine, currently under consideration for the Albian mega-mine site, would increase greenhouse gas emissions by 1.18 million metric tons per year. "If Keystone is approved then we're locking in a several more decades of dependence on fossil fuels," says climate modeler Daniel Harvey of the University of Toronto. "That means higher CO2 emissions, higher concentrations [in the atmosphere] and greater warming that our children and grandchildren have to deal with."

And then there's all the carbon that has to come out of the bitumen to turn it into a usable crude oil.

Hidden carbon
In the U.S. State Department's review of the potential environmental impacts of the Keystone project, consultants EnSys Energy suggested that building the pipeline would not have "any significant impact" on greenhouse gas emissions, largely because Canada's tar sands would likely be developed anyway. But the Keystone pipeline represents the ability to carry away an additional 830,000 barrels per day?and the Albertan tar sands are already bumping up against constraints in the ability to move their product. That has led some to begin shipping the oil by train, truck and barge?further increasing the greenhouse gas emissions?and there is a proposal to build a new rail line, capable of carrying five million barrels of oil per year from Fort McMurray to Alaska's Valdez oil terminal.

Then there's the carbon hidden in the bitumen itself. Either near oil sands mines in the mini-refineries known as upgraders or farther south after the bitumen has reached Midwestern or Gulf Coast refineries, its long, tarry hydrocarbon chains are cracked into the shorter, lighter hydrocarbons used as gasoline, diesel and jet fuel. The residue of this process is a nearly pure black carbon known as petroleum (pet) coke that, if it builds up, has to be blasted loose, as if mining for coal in industrial equipment. The coke is, in fact, a kind of coal and is often burned in the dirtiest fossil fuel's stead. Canadian tar sands upgraders produce roughly 10 million metric tons of the stuff annually, whereas U.S. refineries pump out more than 61 million metric tons per year.

Pet coke is possibly the dirtiest fossil fuel available, emitting at least 30 percent more CO2 per ton than an equivalent amount of the lowest quality mined coals. According to multiple reports from independent analysts, the production (and eventual burning) of such petroleum coke is not included in industry estimates of tar sands greenhouse gas emissions because it is a co-product. Even without it, the Congressional Research Service estimates that tar sands oil results in at least 14 percent more greenhouse gas emissions than do more conventional crude oils.

Although tar sands may be among the least climate-friendly oil produced at present?edging out alternatives such as fracking for oil trapped in shale deposits in North Dakota and flaring the gas?the industry has made attempts to reduce greenhouse gas pollution, unlike other oil-producing regions. For example, there are alternatives to cracking bitumen and making pet coke, albeit more expensive ones, such as adding hydrogen to the cracked bitumen, a process that leaves little carbon behind, employed by Shell, among others.

More recently, Shell has begun adding carbon-capture-and-storage (CCS) technology to capture the emissions from a few of its own upgraders, a project known as Quest. The program, when completed in 2015, will aim to capture and store one million metric tons of CO2 per year, or a little more than a third of the CO2 emissions of Shell's operation at that site. And tar sands producers do face a price on carbon?$15 per metric ton by Alberta provincial regulation?for any emissions above a goal of reducing by 12 percent the total amount of greenhouse gas emitted per total number of barrels produced.

The funds collected?some $312 million to date?are then used to invest in clean technology, but more than 75 percent of the projects are focused on reducing emissions from oil sands, unconventional oils and other fossil fuels. And to drive more companies to implement CCS in the oil sands would require a carbon price of $100 per metric ton or more. "We don't have a price on carbon in the province that is compelling companies to pursue CCS," Pembina's Grant argues.

In fact, Alberta's carbon price may be little more than political cover. "It gives us some ammunition when people attack us for our carbon footprint, if nothing else," former Alberta Energy Minister Ron Liepert told Scientific American in September 2011. Adds Beverly Yee, assistant deputy minister at Alberta's Environment and Sustainable Resource Development agency, more recently, "Greenhouse gases? We don't see that as a regional issue." From the individual driver in the U.S. to oil sands workers and on up to the highest echelons of government in North America, everyone dodges responsibility.

Price of carbon
A true price on carbon, one that incorporates all the damages that could be inflicted by catastrophic climate change, is exactly what Hansen believes is needed to ensure that more fossil fuels, like the tar sands, stay buried. In his preferred scheme, a price on carbon that slowly ratcheted up would be collected either where the fossil fuel comes out of the ground or enters a given country, such as at a port. But instead of that tax filling government coffers, the collected revenue should be rebated in full to all legal residents in equal amounts?an approach he calls fee and dividend. "Not one penny to reducing the national debt or off-setting some other tax," the government scientist argues. "Those are euphemisms for giving the money to government, allowing them to spend more."

Such a carbon tax would make fossil fuels more expensive than alternatives, whether renewable resources such as wind and sun or low-carbon nuclear power. As a result, these latter technologies might begin to displace things like coal-burning power plants or halt major investments in oil infrastructure like the Keystone XL pipeline.

As it stands, producing 1.8 million barrels per day of tar sands oil resulted in the emissions of some 47.1 million metric tons of CO2-equivalent in 2011, up nearly 2 percent from the year before and still growing, according to the Canadian Association of Petroleum Producers. In the same year coal-fired power plants in the U.S. emitted more than two billion metric tons of CO2-equivalent. "If you think that using other petroleum sources is much better [than tar sands], then you're delusional," says chemical engineer Murray Gray, scientific director of the Center for Oil Sands Innovation at the University of Alberta.

In other words, tar sands are just a part of the fossil-fuel addiction?but still an important part. Projects either approved or under construction would expand tar sands production to over five million barrels per day by 2030. "Any expansion of an energy system that relies on the atmosphere to be its waste dump is bad news, whereas expansion of safe, affordable and environmentally acceptable energy technologies is good news," Carnegie's Caldeira says.

There's a lot of bad news these days then, from fracking shale for gas and oil in the U.S. to new coal mines in China. Oxford's Allen calculates that the world needs to begin reducing emissions by roughly 2.5 percent per year, starting now, in order to hit the trillion metric ton target by 2050. Instead emissions hit a new record this past year, increasing 3 percent to 34.7 billion metric tons of CO2 and other greenhouse gases.

Stopping even more bad news is why Hansen expects to be arrested again, whether at a protest against mountaintop removal mining for coal in West Virginia or a sit-in outside the White House to convince the Obama administration to say no to Keystone XL and any expansion of the tar sands industry. The Obama administration has already approved the southern half of the pipeline proposal?and if the northern link is approved, a decision expected after March of this year, environmental group Oil Change International estimates that tar sands refined on the Gulf Coast would produce 16.6 million metric tons of CO2 annually just from the petroleum coke, which would be enough to fuel five coal-fired power plants for a year. All told, the increased tar sands production as a result of opening Keystone would be equal to opening six new coal-fired power plants, according to Pembina Institute calculations.

Even as increased oil production in the U.S. diminishes the demand for tar sands-derived fuel domestically, if Keystone reaches the Gulf Coast, that oil will still be refined and exported. At the same time, Obama pledged to respond to climate change and argued for U.S. leadership in the transition to "sustainable energy sources" during his second inaugural address; approving Keystone might lead in the opposite direction.

For the tar sands "the climate forcing per unit energy is higher than most fossil fuels," argues Hansen, who believes he is fighting for the global climate his five grandchildren will endure?or enjoy. After all, none of his grandchildren have lived through a month with colder than average daily temperatures. There has not been one in the U.S. since February 1985, before even Hansen started testifying on global warming. As he says: "Going after tar sands?incredibly dirty, destroying the local environment for a very carbon-intensive fuel?is the sign of a terribly crazed addict."

Source: http://rss.sciam.com/click.phdo?i=c090239aa6d1cebc20edcb59f905c827

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Thursday, January 24, 2013

Chrysler near a deal for preferred lender - Automotive News

DETROIT -- Chrysler Group is close to signing a new preferred auto lender that promises to boost leasing for dealers.

Chrysler-Fiat CEO Sergio Marchionne said the automaker is "in the final stretch" of negotiations with the financial services provider, which he did not name. The Wall Street Journal, citing unnamed sources, reported that the lender is Spain's Banco Santander.

The lender will replace Ally Financial Inc. as the primary lender to dealers and customers.

Marchionne said at the Detroit auto show last week that the agreement would allow Chrysler dealers to increase shoppers' leasing options, which in turn can boost vehicle sales by qualifying more consumers for financing.

"We understand that there's a piece of the market that we're not currently accessing," Marchionne said. "Whether we do it directly or 100 percent through a provider or in a combination with other sources, it really doesn't matter. But we'll be there."

Reid Bigland, head of U.S. sales, said Chrysler has some leasing programs in place but they account for only 10 to 13 percent of U.S. sales while the industry average is about 20 percent. "I think in any arrangement that we put forward, it will have a leasing element," he said. "How much leasing is just going to kind of depend on the dealers and the market."

The arrangement would only cover sales in the United States, not in Canada.

Under previous owner Cerberus Capital Management, Chrysler abruptly ended leasing in July 2008 when financing through Chrysler Financial, Chrysler's former captive finance arm, evaporated. Without leasing options, sales of Chrysler vehicles fell sharply.

Since taking over Chrysler, Marchionne has said repeatedly that the company doesn't need a captive finance arm to boost sales, despite dealer desires for an in-house lender. Marchionne said Chrysler should concentrate on making profitable vehicles instead of trying to make profits from auto financing.

But in comments to Automotive News last week, Marchionne said the new preferred lender will operate in much the same way as other automakers' in-house lenders, and might even have Chrysler in its name.

"It will look and smell like a captive arm," he said. "This sounds like a European solution, but if I can use your balance sheet and my name, I think we're going to be fine."

You can reach Larry P. Vellequette at lvellequette@crain.com.

Source: http://www.autonews.com/article/20130123/FINANCE_AND_INSURANCE/301239997/chrysler-near-a-deal-for-preferred-lender

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Wednesday, January 23, 2013

Netflix lost $105 million on international streaming business in Q4 ...







- ABRAXANE m?s gemcitabine demostr? unos resultados estad?stica y cl?nicamente significativos en los criterios primarios y secundarios y en subgrupos de pacientes

- Los pacientes de ABRAXANE m?s gemcitabine mostraron un 59% m?s de opci?n de supervivencia en el a?o uno; las tasas de supervivencia se duplicaron en dos a?os

- Un nuevo est?ndar de cuidado para pacientes con c?ncer pancre?tico avanzado

- Presentaci?n oral prevista para el viernes, 25 de enero en el Gastrointestinal Cancers Symposium Annual Meeting de ASCO

MELBOURNE, Australia, 24 de enero de 2013 /PRNewswire/ ? La compa??a biofarmac?utica australiana Specialised Therapeutics Australia anuncia que un ensayo cl?nico de fase III del f?rmaco l?der para el c?ncer de mama ABRAXANE? (nanoparticle albumin-bound paclitaxel) en combinaci?n con el actual est?ndar de cuidado gemcitabine en pacientes con c?ncer pancre?tico avanzado ha demostrado un tiempo de supervivencia sustancialmente mejorado, con una tasa de supervivencia de dos a?os del doble de pacientes.(1)

La investigaci?n MPACT (Metastatic Pancreatic Adenocarcinoma Clinical Trial) implic? a 861 pacientes que no hab?an recibido tratamiento previo internacionalmente. ?

Los investigadores descubrieron que los pacientes tratados con ABRAXANE m?s gemcitabine tuvieron una mejora estad?sticamente significativa en la supervivencia general en comparaci?n con pacientes que recibieron solo gemcitabine [(media de 8,5 vs. 6,7 meses) (HR 0,72, P=0,000015)].(1)

Adem?s, ABRAXANE m?s gemcitabine demostr? un aumento del 59% en la supervivencia al a?o (35% vs. 22%, p=0,0002) y demostr? duplicar la tasa de supervivencia a los dos a?os (9% vs. 4%, p=0,02) en comparaci?n con solo gemcitabine.(1)

ABRAXANE m?s gemcitabine tambi?n demostr? mejoras estad?sticamente significativas en criterios secundarios clave comparados con solo gemcitabine, incluyendo una reducci?n del 31% en el riesgo de progresi?n o muerte con una supervivencia sin progresi?n (PFS) media de 5,5 vs. 3,7 meses (HR 0,69, P=0,000024) y una tasa de respuesta general (ORR) del 23% en comparaci?n con el 7% (ratio de la tasa de respuesta de 3,19, p=1,1 x 10-10).? Otro criterio evaluado incluy? tiempo para el fallo del tratamiento, que se mejor? significativamente con la combinaci?n de ABRAXANE en comparaci?n con solo gemcitabine [(media de 5,1 vs. 3,6 meses) (HR 0,70, P<0,0001)].(1)

?Las ?ltimas d?cadas nos han tra?do muy pocos avances de tratamiento para pacientes con c?ncer pancre?tico avanzado, que es mortal o incre?blemente dif?cil de tratar con ?xito?, dijo Daniel D. Von Hoff , M.D., F.A.C.P., investigador principal del estudio MPACT y director cient?fico para Scottsdale Healthcare?s Virginia G. Piper Cancer Centre Clinical Trials y m?dico jefe de TGen. ?El hecho de que ABRAXANE m?s gemcitabine demostrase un beneficio de supervivencia general y tambi?n lo hiciera en uno y dos a?os, es un importante paso hacia delante en ofrecer una nueva esperanza para nuestros pacientes?.

El profesor John Zalcberg,?director m?dico y director ejecutivo de medicina para el c?ncer en el Peter MacCallum Cancer Centre en Melbourne, dijo que la evidencia respaldaba fuertemente el uso de ABRAXANE en combinaci?n con gemcitabine como un nuevo est?ndar de cuidado para tratar a los pacientes adecuados, muchos de los cuales no estaban diagnosticados hasta que la enfermedad era metast?sica.

Aunque se reconoce que este avance no se ver?a como una cura para el c?ncer pancre?tico, el profesor Zalcberg dijo que el aumento del 59% en el n?mero de pacientes que viv?an m?s de 12 meses era muy alentador. ?

?Estamos muy animados por los resultados de este estudio sobre ABRAXANE y vemos este resultado como una importante revoluci?n en t?rminos de tratamiento futuro de esta enfermedad?, dijo.

?Adem?s de tratar a mujeres con c?ncer de mama metast?sico con ABRAXANE en el entorno adecuado, esperamos su aprobaci?n en Australia para tratar a pacientes con c?ncer pancre?tico avanzado?.

El consejero delegado de Specialised Therapeutics Australia (STA), Carlo Montagner dijo que los datos positivos abrieron el camino para los pacientes australianos con c?ncer pancre?tico avanzado para acceder a opciones de tratamiento m?s efectivas.

?En Australia, el c?ncer pancre?tico es la cuarta causa m?s com?n de muerte por c?ncer para hombres y mujeres(2) y existen muy pocas opciones de tratamiento para este grupo de pacientes. Estamos extremadamente satisfechos por haber demostrado que ABRAXANE es capaz de prolongar la supervivencia de pacientes con c?ncer pancre?tico avanzado y esperamos que ABRAXANE se apruebe por la Australian Therapeutic Goods Administration (TGA) en la segunda mitad de 2014?, coment?.

Los efectos secundarios relacionados con el tratamiento de grado ? 3 m?s comunes en el estudio de ABRAXANE m?s gemcitabine vs. gemcitabine solo fueron neutropenia (38% vs. 27%), fatiga (17% vs. 7%) y neuropat?a (17% vs. 1%).? En el brazo de ABRAXANE m?s gemcitabine, el tiempo medio de mejora de la neuropat?a fue de 29 d?as. No hubo diferencia en la toxicidad como amenaza grave para la vida (4% en cada brazo).(1)

Otros detalles del estudio se destacar?n en una presentaci?n oral por el doctor Daniel D. Von Hoff :

  • Abstract: LBA #148: Resultados finales de un estudio de fase III aleatorio de nab-paclitaxel semanal m?s gemcitabine frente a gemcitabine solo en pacientes con adenocarcinoma metast?tico de p?ncreas. El viernes 25 de enero entre las 2:00 y las 3:30 pm PST en el American Society of Clinical Oncology?s (ASCO) 2013 Gastrointestinal Cancers Symposium en San Francisco, CA.

Estos resultados pertenecen a un estudio investigacional. ABRAXANE no est? aprobado para el tratamiento del c?ncer pancre?tico avanzado. Tras la revisi?n y aprobaci?n TGA, STA buscar? tener ABRAXANE incluido en el Pharmaceutical Benefits Scheme (PBS) para el reembolso de ABRAXANE para el c?ncer pancre?tico avanzado. ?

Acerca del estudio MPACT (1)

En el ensayo MPACT (Metastatic Pancreatic Adenocarcinoma Clinical Trial) un ensayo internacional patrocinado por Celgene, abierto, controlado y aleatorio, 861 pacientes con c?ncer de p?ncreas matast?tico fueron tratados de forma aleatoria con ABRAXANE mas gemcitabina (125 mg/m2 y luego 1000 mg/m2 gemcitabina durante 3 semanas seguidas de una semana del resto) o gemcitabina sola (1000 mg/m2 administrada semanalmente durante 7 semanas seguidas de una semana del resto y luego en ciclos de administraci?n semanal durante 3 semanas seguidas de una semana del resto).

El principal criterio de valoraci?n del ensayo es la mejora de la supervivencia general y la tasa de respuesta general determinada por la revisi?n radiol?gica independiente. Los criterios de valoraci?n secundarios incluyeron la evaluaci?n de la supervivencia sin evoluci?n, la tasa de respuesta global determinada por el investigador y la seguridad y la tolerancia de esta combinaci?n en esta poblaci?n de pacientes.

Acerca del c?ncer pancre?tico avanzado

El c?ncer pancre?tico avanzado es un c?ncer dif?cil de tratar con las menores tasas de supervivencia entre todos los tipos de c?ncer.? En todos los pacientes con c?ncer pancre?tico, la supervivencia relativa a los cinco a?os es del 6% y es menor del 2% para los que padecen la enfermedad en estado avanzado. ?Hay dos tipos principales de c?ncer pancre?tico: adenocarcinomas, que es el responsable de aproximadamente el 90% de todos los c?nceres pancre?ticos, y los tumores neuroendocrinos. El c?ncer pancre?tico es relativamente poco com?n con nuevos casos que suponen solo el 2,1% de todos los c?nceres recientemente diagnosticados. Sin embargo, el c?ncer pancre?tico es la cuarta causa m?s com?n de c?ncer para hombres y mujeres en Estados Unidos y Australia, y el noveno c?ncer m?s com?nmente diagnosticado en Australia.(2)?

Acerca de ABRAXANE??

ABRAXANE es una opci?n de tratamiento con quimioterapia de nanopart?culas sin disolvente para el c?ncer de mama metast?sico.(3) En Australia, ABRAXANE se incluye actualmente en PBS para el tratamiento del c?ncer de mama metast?tico y c?ncer de mama HER2 positivo en combinaci?n con ?trastuzumab.

ABRAXANE se aprueba para el c?ncer de mama metast?sico en m?s de 40 pa?ses, como Estados Unidos, Canad?, la Uni?n Europea, Jap?n y China, y m?s de 500.000 pacientes con c?ncer han recibido la terapia ABRAXANE en los ?ltimos cinco a?os. ?

En Australia, ABRAXANE ha recibido la designaci?n de f?rmaco hu?rfano por la Therapeutic Goods Administration para el tratamiento del c?ncer pancre?tico. El estatus de f?rmaco hu?rfano se concede a f?rmacos utilizados para tratar enfermedades relativamente raras como el c?ncer pancre?tico y pueden permitir la evaluaci?n de prioridad por la TGA.

ABRAXANE est? actualmente en varias fases de investigaci?n para el tratamiento de los siguientes c?nceres: melanoma metast?sico, vejiga, ovario,?y aplicaciones expandidas para el c?ncer de mama.

Desarrollado utilizando la plataforma de tecnolog?a patentada nab?, ABRAXANE es un agente de quimioterapia de prote?na de nanopart?cula. ABRAXANE combina paclitaxel con alb?mina, una prote?na humana que se produce naturalmente, para suministrar el f?rmaco y elimina la necesidad de disolventes en el proceso de administraci?n. La tecnolog?a de nanopart?culas permite a ABRAXANE suministrar una dosis un 49% mayor en comparaci?n con paclitaxel regular basado en disolventes sin comprometer la seguridad y la tolerabilidad.(3-4)

En un estudio de fase III aleatorio de pacientes con c?ncer de mama metast?sico, ABRAXANE demostr? casi duplicar la tasa de respuesta del tumor general en comparaci?n con paclitaxel basado en disolventes. (3-4)

Los pacientes tratados previamente con antraciclina en el estudio vivieron significativamente m?s.5 La tolerabilidad con ABRAXANE y el paclitaxel basado en disolventes fue comparable, a pesar de una dosis un 49% mayor de paclitaxel administrado como ABRAXANE.(3-4) La neutropenia era menor con ABRAXANE en comparaci?n con paclitaxel basado en disolventes, aunque hubo un aumento en la incidencia de neuropat?a perif?rica de grado 3 con ?ABRAXANE. Sin embargo, el tiempo medio para la mejora, desde la neuropat?a perif?rica de grado 3 a la de grado 2 o menor, fue de 22 d?as. No se notific? ning?n efecto secundario conocido para paclitaxel.(3-4)

Contraindicaciones y efectos secundarios(3):

Al igual que todos los medicamentos, ABRAXANE podr?a causar efectos secundarios. ?

ABRAXANE no deber?a utilizarse en pacientes que tienen un recuento de neutr?filos de l?nea base de <1,5 x 109 /L.

En pacientes que han demostrado reacciones de hipersensibilidad a paclitaxel o alb?mina, los pacientes no deber?an ser tratados con ABRAXANE.

ABRAXANE est? contraindicado durante el embarazo y lactancia.

Los efectos secundarios m?s comunes (?1/10) causados por ABRAXANE son: neutropenia, anemia, leucopenia, trombocitopenia, linfopenia, anorexia, neuropat?a perif?rica, hipoestesia, paraetesia, n?usea, diarrea, v?mitos, estre?imiento, estomatitis, alopecia, sarpullidos, artralgia, mialgia, fatiga, astenia, pirexia.

Para m?s informaci?n sobre ABRAXANE y los posibles efectos secundarios, los m?dicos deber?an revisar la informaci?n de producto ABRAXANE y los pacientes deber?an consultar con sus onc?logos o con la informaci?n sobre medicamentos de consumo ABRAXANE disponible en www.specialisedtherapeutics.com.au.

ABRAXANE??es una marca comercial registrada de Celgene Corporation.

ABRAXANE??se distribuye por STA bajo la licencia de Celgene Corporation en Australia y Nueva Zelanda.

Acerca de Specialised Therapeutics Australia Pty Ltd

Specialised Therapeutics Australia Pty Ltd (STA) es una compa??a biofarmac?utica dedicada a trabajar con las principales compa??as biofarmac?uticas del mundo para proporcionar terapias con tratamiento agudos para necesidades m?dicas no cumplidas de cara a las personas que viven en Australia y Nueva Zelanda. ?

Actualmente, STA comercializa dos de las principales terapias de c?ncer y de tratamiento de apoyo al c?ncer del mundo, ABRAXANE? (nab-paclitaxel) y ALOXI? (palonosetron HCl) respectivamente, y ha licenciado recientemente dos nuevos agentes a trav?s de Helsinn Group. Primero Anamorelin, un nuevo agonista receptor de ghrelin para el tratamiento de anorexia-cachexia en NSCLC y un producto de combinaci?n de dosis fija (en formas tanto oral como intravenosa) que contiene netupitant, un antagonista receptor de la neuroquinina 1 (NK1), y Aloxi?, un antagonista receptor de la serotonina 3 (5-HT3). STA tiene tambi?n inter?s en las ?reas terap?uticas de los antiinfecciosos con los derechos para comercializar DIFICID? (fidaxomicin) para el tratamiento de las infecciones por Clostridium difficile, respiratorias, dermatol?gicas, endocrinol?gicas y del sistema nervioso central (SNC). Informaci?n adicional disponible por medio de http://www.specialisedtherapeutics.com.au

Referencias:

  1. Von Hoff DD et al. Abstract: LBA #148: Final results of a randomized phase III study of weekly nab-paclitaxel plus gemcitabine versus gemcitabine alone in patients with metastatic adenocarcinoma of the pancreas. ASCO GI 2013
  2. Cancer in Australia. An Overview 2012. Australian Institute of Health and Welfare (AIHW)
  3. Abraxane Product Information
  4. Gradishar WJ et al. J Clinical Oncology 2005;23:7794-7803
  5. Vukelja SJ et al. ASCO 2008, Abstract 1082

Consultas de medios:

Emma Power
Monsoon Communications
Level 12 15 William Street
Melbourne VIC 3000
Tel: +61-3-9620-3333

SOURCE Specialised Therapeutics Australia Pty Ltd

RELATED LINKS
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A shot at the truth about gun violence

The best ways to prevent gun-related crime have never been properly investigated. It is time for the scientific evidence to trump ideology

LOVE it or loathe it, there is no denying that the US National Rifle Association (NRA) has been stunningly successful in its efforts to fight gun control. In the 1990s, it even managed to largely shut down US government research into gun violence as a public-health problem - an unbelievable situation that still stands today.

This is why President Obama's clear instruction to the Centers for Disease Control and Prevention to initiate research into reducing gun violence is important and necessary (see "Obama to scientists: Tell us how to calm gun violence").

But it is only the first step. Deciding whether to fund the research will be down to Congress, where the NRA's influence still holds strong.

If the NRA succeeds in blocking this attempt to bring science to bear on America's gun problem, it will be another demoralising example of the power of money over evidence-based politics.

The NRA presents itself as a civil rights group dedicated to upholding and defending the Second Amendment to the US Constitution - the one about the right to "keep and bear arms". The gun lobby interprets this as an inalienable individual right to own guns.

Although the NRA was founded on this platform, it is important to recognise that it has strong links to the firearms industry, which supplies it with millions of dollars in funding.

Viewed from this perspective, the NRA's strangling of research is utterly reprehensible. Imagine if a group associated with food manufacturers were able to curtail research on obesity, or if tobacco interests had nixed the science that tied smoking to lung cancer.

Hopefully we will now get some fresh answers on the best approaches to preventing gun violence. But if this knowledge is to be acted on, politicians and the public on both sides will need to abandon entrenched positions.

Liberal opponents of the gun lobby often assume that the answer lies in tougher restrictions on ownership - but that isn't necessarily where the biggest gains could be made.

Advocates for gun rights must accept that public-health researchers aren't the stooges of a sinister bureaucracy intent on seizing their guns. They are professionals trying to use the scientific method to save lives. They should be set free to do this work, and then listened to.

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No boys' club here: New Hampshire's all-women delegation (cbsnews)

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Tuesday, January 22, 2013

A day pulsing with history follows very old script

WASHINGTON (AP) ? It was altogether a more intimate affair than four years ago. Just a party of untold hundred thousands, chilling in the nation's backyard.

President Barack Obama's inauguration Monday brought out a festive crowd of flag-wavers who filled the National Mall to overflowing, hailed his moment with lusty cheers and spent their down time spotting celebrities amid the bunting.

No match for the staggering masses and adrenaline-pumping energy of his first turn as president on the west front of the Capitol. But a lively second act.

After a roaring rendition of the "Battle Hymn of the Republic" came James Taylor strumming his guitar and singing "America the Beautiful." Then an all-for-show swearing-in, replicating the official one Sunday.

Then Obama spoke, as all presidents must in one way or another, about "one nation and one people," healing words after a battering ram of an election and before the partisan struggles ahead. The address clocked in at 18 minutes, about the same as in 2009.

Sharon Davis of Suitland, Md., retired after 22 years in the Air Force, said it all made her proud beyond words. "There's a lot of energy here today," she said. "But it doesn't compare to last time, when it was just off the charts."

Spectators stood five to six deep along the broad sweep of Pennsylvania Avenue for the afternoon inaugural parade, featuring more than 8,800 military and civilian participants in floats, marching bands, dance troupes and more. Chinese-American folk dancers from Delaware, a Kansas University trumpet ensemble, Boston College "Screaming Eagles" and Idaho firefighters contributed to the eclectic mix.

It took 90 minutes for Katasha Smart of Randallstown, Md., to get through security and into position for the parade after walking from near the Washington Monument, where video and audio malfunctions made Obama's address hard to see and hear.

"The energy level is lower," she said. "Before it was just so exciting ? you could be walking for miles and miles and it didn't even feel like an effort."

The excitement picked up, though, when the Obamas came by in the parade and made the all-but-obligatory exit from their limousine to walk for a few minutes. Shouts of "Get out!" turned to happy chants of his name. He and his wife, Michelle, blew kisses to the spectators before getting back in the car.

Hours before the pageantry, people on foot spilled out of Metro stations near the White House and streamed toward the scene, official vehicles sealed off intersections blocks from the White House and Obama stood for a blessing in the "Church of Presidents."

The service at St. John's Episcopal Church captured the intended tone of the day: unity. Bishop Vashti McKenzie of the African Methodist Episcopal Church spoke in the blessing of "this new season of opportunity after conflicting opinions and visions and platforms clanged against each other like a resounding gong. "

A sea of people filled stretches of the National Mall from the west front of the Capitol back to the Washington Monument and beyond, to the reflecting pool. No one expected a repeat of the unprecedented crowds of four years ago. But for many thousands, it was not to be missed.

David Richardson, 45, brought his children, Camille, 5, and Miles, 8, from Atlanta to soak it all in and to show them, in Obama's achievement, that "anything is possible through hard work."

The "mostly Republican" Vicki Lyons, 51, of Lakewood, Colo., called the experience "surreal" and "like standing in the middle of history."

She didn't vote for Obama and voiced plenty of worry about the nation's future but said: "No matter who the president is, everybody needs to do this at least once."

Outside the Capitol, scene of Obama's noontime inaugural speech, people had their pictures taken with the flag-draped building in the background. Justices, lawmakers, Cabinet members and former presidents Bill Clinton and Jimmy Carter filled prime seats. Katy Perry, Eva Longoria and John Mayer were among stars on the platform. Kelly Clarkson sang "My Country, 'Tis of Thee," and Beyonce closed with the national anthem.

It was overcast with a breeze, 40 degrees at noon, sparing the crowd the biting cold morning of four years earlier.

Kenya Strong, a 37-year-old financial analyst from Charlotte, N.C., brought her daughter, Ty, for the second time. Like Richardson, she said the event holds lessons for the young.

"It's really important for her to understand that her potential is endless," she said. "You have so much to live and look forward to, for yourself personally, for our country ? just to see that there's more than the here and now."

Ty Strong, now 15, toted a new camera and broader expectations than in 2009 about the kind of people she'd meet ? not just African-Americans like herself.

"There were a lot of different faces among the crowd that you don't expect to see on an everyday basis ? like more foreigners," she said. "It was nice."

At midmorning, Metro subway trains through downtown Washington were no more crowded than they would be on a typical workday ? except few were going to work.

Transit officials said 308,000 train passengers entered the system as of 11 a.m., down 40 percent from the same period in the 2009 inauguration.

Terry Alexander, a Democratic state representative from South Carolina, and his wife, Starlee Alexander, were taking a leisurely ride from their downtown hotel to Union Station. Four years ago, they had to ride a bus to the Pentagon from their Virginia hotel and walk across the 14th Street Bridge to the National Mall.

"It was crazy," he said. "This is calm. Last time, we couldn't even get down in the tunnel to get to the trains."

Obama's motorcade went into motion several hours before the speech, taking him with his family to St. John's Episcopal Church. Before the sermon, R&B performer Ledisi sang the solo "I Feel Like Goin' On."

On recent visits to the "Church of Presidents," Obama has taken to ditching the motorcade in favor of walking back to the White House through Lafayette Park.

But this was a day for a speech, a parade and the many decorative rituals of power, not an idle stroll.

His inaugural speech over, heading into the Capitol before a luncheon of bison and lobster in Statuary Hall, Obama briefly lingered and turned his gaze back to the crowd.

"I want to take a look, one more time," he said. "I'm not going to see this again."

___

Associated Press writers Richard Lardner, Alan Fram, Darlene Superville, Ben Nuckols, David Dishneau, Donna Cassata, Nancy Benac and Matthew Barakat contributed to this report.

Source: http://news.yahoo.com/day-pulsing-history-follows-very-old-script-140009723--politics.html

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Desert siege toll passes 80; bomb squads search

In this image made from video, a group of people believed to be hostages kneel in the sand with their hands in the air at an unknown location in Algeria. Algerian de-mining teams were scouring a gas refinery on Sunday, Jan. 20, 2013 that was the scene of a bloody four-day standoff, searching for explosive traps left by the Islamist militants who took dozens of foreigners hostage. The siege left at least 23 captives dead, and the American government warned that there were credible threats of more kidnapping attempts on Westerners. (AP Photo/Ennahar TV) ALGERIA OUT, TV OUT

In this image made from video, a group of people believed to be hostages kneel in the sand with their hands in the air at an unknown location in Algeria. Algerian de-mining teams were scouring a gas refinery on Sunday, Jan. 20, 2013 that was the scene of a bloody four-day standoff, searching for explosive traps left by the Islamist militants who took dozens of foreigners hostage. The siege left at least 23 captives dead, and the American government warned that there were credible threats of more kidnapping attempts on Westerners. (AP Photo/Ennahar TV) ALGERIA OUT, TV OUT

In this image made from video, a group of people believed to be hostages kneel in the sand with their hands in the air at an unknown location in Algeria. An Algerian security official says de-mining squads searching for explosives found "numerous" bodies Sunday, Jan. 20, 2012 at a gas refinery where Islamic militants took dozens of foreign workers hostage. (AP Photo/Ennahar TV) ALGERIA OUT, TV OUT

Algerian special police unit officers guard the entrance of an hospital located near the gas plant where hostages have been kidnapped by Islamic militants, in Ain Amenas, Saturday, Jan. 19, 2013. Algeria's special forces stormed the natural gas complex in the middle of the Sahara desert in a final assault Saturday, killing 11 militants, but not before they in turn killed seven hostages, the state news agency reported.(AP Photo/Anis Belghoul)

Norway's Prime Minister Jens Stoltenberg is embraced by Executive Vice President in Statoil, Margrethe Oevrum, Saturday Jan. 19, 2013, after his visit at the drop-in center in Bergen for relatives of the Statoil-employees taken hostage in Algeria. In a bloody finale on Saturday, Algerian special forces stormed a natural gas complex in the Sahara desert to end a four-day standoff with Islamic extremists that left at least 19 hostages and 29 militants dead. With few details emerging from the remote site, it was unclear whether anyone was rescued in the final operation. (AP Photo / Anette Karlsen, NTB scanpix) NORWAY OUT

Two British hostages Peter, left, and Alan, right, (no family name available), are seen after being released, in a street of Ain Amenas, near the gas plant where they have been kidnapped by Islamic militants, Saturday, Jan. 19, 2013. Algeria's special forces stormed the natural gas complex in the middle of the Sahara desert in a final assault Saturday, killing 11 militants, but not before they in turn killed seven hostages, the state news agency reported.(AP Photo/Anis Belghoul)

(AP) ? Algerian bomb squads searched a gas refinery laced with mines on Monday, looking for more explosive traps a day after the discovery of more bodies throughout the site raised the toll from the terrorist siege well past 80.

Special forces from the Algerian military stormed the plant on Saturday to end the four-day siege, then the government began the painstaking work of finding and defusing the explosives planted in what government officials said was a plot by the Islamic extremists to blow up the complex and kill all their captives.

In a statement, the Masked Brigade, the group that claimed to have masterminded the takeover, warned of more such attacks against any country backing France's military intervention in neighboring Mali, where the French are trying to stop an advance by Islamic extremists.

"We stress to our Muslim brothers the necessity to stay away from all the Western companies and complexes for their own safety, and especially the French ones," the statement said.

Algeria said after Saturday's assault by government forces that at least 32 extremists and 23 hostages were killed. On Sunday, the Algerian bomb squads found 25 more bodies, said a security official, who spoke on condition of anonymity because of the sensitivity of the situation.

"These bodies are difficult to identify. They could be the bodies of foreign hostages or Algerians or terrorists," the official said.

In addition, a wounded Romanian who had been evacuated died, raising the overall death toll to at least 81.

Two private Algerian TV stations and an online news site said security forces scouring the plant found five militants hiding out on Sunday and learned that three others had fled. That information could not be immediately confirmed by security officials.

"Now, of course, people will ask questions about the Algerian response to these events, but I would just say that the responsibility for these deaths lies squarely with the terrorists who launched a vicious and cowardly attack," British Prime Minister David Cameron said. Three Britons were killed and another three were feared dead.

On Monday, Philippine Foreign Affairs officials said six Filipinos were among the hostages killed. Spokesman Raul Hernandez told reporters that 16 Filipinos have been accounted for and four others are still missing.

The dead hostages were also known to include at least one American and a French worker. Nearly two dozen foreigners by some estimates were unaccounted for.

It was unclear whether anyone was rescued in the final assault on the complex, which is run by the Algerian state oil company along with BP and Norway's Statoil.

Authorities said the bloody takeover was carried out Wednesday by 32 men from six countries, under the command from afar of the one-eyed Algerian bandit Moktar Belmoktar, founder of the Masked Brigade, based in Mali. The attacking force called itself "Those Who Sign in Blood" and has claimed to have Canadians in the cell as well.

The Masked Brigade said Sunday the attack was payback against Algeria for allowing over-flights of French aircraft headed to Mali and for closing its long border with Mali. In an earlier communication, the Brigade claimed to have carried out the attack in the name of al-Qaida.

Armed with heavy machine guns, rocket launchers, missiles and grenades, the militants singled out foreign workers at the plant, killing some of them on the spot and attaching explosive belts to others.

Algeria's tough and uncompromising response to the crisis was typical of its take-no-prisoners approach in confronting terrorists, favoring military action over negotiation. Algerian military forces, backed by attack helicopters, launched two assaults on the plant, the first one on Thursday.

The militants had "decided to succeed in the operation as planned, to blow up the gas complex and kill all the hostages," Algerian Communications Minister Mohamed Said told state radio.

Norwegian Foreign Minister Espen Barth Eide said the terrorists had tried to blow up the plant on Saturday but managed only to start a small fire. "That's when they started to execute hostages, and the special forces intervened," Eide said. Norway's Statoil said five Norwegians were still missing.

An audio recording of Algerian security forces speaking with the head of the kidnappers, Abdel Rahman al-Nigiri, on the second day of the drama indicated the hostage-takers were trying to organize a prisoner swap.

"You see our demands are so easy, so easy if you want to negotiate with us," al-Nigiri said in the recording broadcast by Algerian television. "We want the prisoners you have, the comrades who were arrested and imprisoned 15 years ago. We want 100 of them."

The Algerians' use of forced raised an international outcry from some countries worried about their citizens.

But French Foreign Minister Laurent Fabius said Sunday on French television: "The terrorists ... they're the ones to blame."

David Plouffe, a senior adviser to President Barack Obama, said that al-Qaida and al-Qaida-affiliated groups remain a threat in North Africa and other parts of the world, and that the U.S. is determined to help other countries destroy those networks.

Speaking on "Fox News Sunday," Plouffe said the tragedy in Algeria shows once again "that all across the globe countries are threatened by terrorists who will use civilians to try and advance their twisted and sick agenda."

___

Ganley reported from Paris. Associated Press writers Paul Schemm in Rabat, Morocco, and Lori Hinnant in Paris also contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-01-21-Algeria-Kidnapping/id-81a77df263414c6ba6eba93dba13f02d

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Monday, January 21, 2013

President / CEO / COO / Chief Operating Officer / EVP (Social ...

Job Description
According to many, ?social commerce? will be the next area to explode, and uQast is poised to be the dominant platform in the space. And we?re looking for an additional leader for our executive team.

If you?re a highly experienced senior executive with a successful track record leading fast-growth tech companies from early rounds to exit, and you have a solid grasp of ecommerce, social media and affiliate/digital/mobile marketing, then this might be the ideal 12 to 36-month opportunity for you.

Current Status
After successful beta testing and >$500K in revenue, the platform is ready to launch in a big way. We?re about to turn on both the free version and the world?s first social ad network.

In a nutshell, it?s like YouTube meets Amazon/iTunes meets Commission Junction or Clickbank . . . with a very compelling, proven business model, many significant innovations, and one patent already issued.

The founder is a well known expert/speaker in the Internet marketing industry, responsible for several of the biggest online product launches. His prior self-funded online businesses went from zero to $30 million in annual revenue in three years, and his last start-up generated $18 million in sales and $3 million in revenue on the very first day.

The CTO is a very experienced hands-on senior team builder, architect and engineer, and both the COO and CFO were senior executives at different Fortune 1,000 companies, and both have start-up experience, as well.

We are currently seeking an executive leader to round out our management team. This individual would serve as a top executive for day-to-day operations, including finance, marketing, sales, and all administrative functions. The position could be called CEO or COO, and/or EVP or President, but with the amount of equity reserved for this person, the current management team members refer to it as ?another partner.?

To Learn More: Watch the short videos at http://www.uQast.com/learn_more.htm.

If Interested: Please reply with a short message, plus your resume or C.V.
Desired Skills & Experience

The ideal candidate will have the following background and characteristics:

College degree (MBA preferred);
Significant experience as the chief or top executive in a fast growth tech company, preferably with demonstrably successful exit(s);
Entrepreneurial/start-up experience. (Yes, we do need to do that, ourselves, for now, and yes, we know that [$company = Fortune(50-1,000)] doesn?t do it that way.)
Experience with raising capital from institutional investors (preferably with a significant personal network in the top/mid-tier VC/PE communities);
Natural talent and significant experience with everything about marketing/branding/positioning (B2C), including driving excellent ideas and design;
Significant experience with Internet marketing, including SEO/SEM, PPC and paid media, and especially affiliate and social/mobile marketing;
At least a working familiarity with online ad networks and ad xchanges;
Proficiency and comfort with all types of current platforms and players for social/mobile/local apps, etc.
Proven track record of high level bizdev, including identifying, presenting, negotiating, and managing relationships with Fortune 1,000 companies;
Extensive management experience, including hiring, motivating, and building and maintaining a world class culture;
Excellent communication skills, including media interviews and persuasive and personable writing;

Superior presentation skills, including both the creation, improvement and delivery of critical business/investor/sales presentations;
Senior management experience with web software development, and/or large scale Internet companies;

Company Description
uQast is a new web site, a platform poised to become the leader in the social commerce space.

We?ve already received one patent for our search algorithm, or our methodology, called ReviewRank, that serves to rank order all types of digital media content, not by the size of the advertising budget, or the quality of the marketing, but by the quality of the content, itself.

In a nutshell, uQast makes it easy for anyone:

To share digital media to build their audience (kind of like YouTube, but for any type of digital media, including audios, ebooks, powerpoints, ringtones, music, software, etc.); and
To sell their digital media products;
Both on uQast.com (like Amazon or iTunes);
And/or on their own web sites by merely adding a buy button (like Clickbank, 1shoppingcart, or gumroad.com).

At the same time, uQast is a brand new type of affiliate network, where affiliates get paid (for the first time), not just for all the sales they actually refer ? but for all the purchases made, by both their customers, and by their free account referrals ? from any merchant on the entire site, for an entire year.

This model and several others could be revolutionary, or even disruptive, in both the affiliate marketing and the online advertising industries.

APPLY HERE

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  1. President / EVP / COO / Chief Operating Officer ? uQast
  2. Vice President ? Public Relations & Social Media ? Affect Inc (NYC)
  3. Chief Marketing Officer ? Mblox (London or California)
  4. Chief Technology Officer, Fox Filmed Entertainment ? LA
  5. EXCLUSIVE INTERVIEW: Frank Cooper 3rd, SVP & Chief Consumer Engagement Officer ? Pepsi Co Americas

Source: http://www.themusicvoid.com/2013/01/president-ceo-coo-chief-operating-officer-evp-social-commerce-platform-uqast/

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Linchpin of skin response to UVA light discovered

Jan. 21, 2013 ? Researchers have strengthened their understanding of how skin cells called melanocytes sense ultraviolet light and act to protect themselves with melanin. In a new study, they report experiments showing that an ion channel well-known elsewhere in the body for its chemical sensitivity, plays a central role in this process.

Last year, a team of researchers at Brown University discovered that certain skin cells use a light-sensitive receptor found outside of the eye to sense ultraviolet light and quickly begin pumping out melanin to protect against DNA damage. In a new study, lab members identify a key player in that biomolecular chain of events that could someday become a pharmacological target for improving this protective response.

The new discovery, published the week of Jan. 21 in the Proceedings of the National Academy of Sciences, is that human melaoncyte skin cells rely on an ion channel called TRPA1 to allow a flood of calcium ions into the cells when they are exposed to UVA light. The resulting abundance of calcium ions signals the cell to begin making melanin, the pigment responsible for the tanning response in people.

The discovery "is exciting because it confirms this phototransduction pathway is similar to those found in the eye."Several experiments described in the paper show that TRPA1, which is known from a number of other appearances elsewhere in the body, is an essential step in the skin's response to UVA light, said senior author Elena Oancea, assistant professor of medical science in the Department of Molecular Pharmacology, Physiology, and Biotechnology at Brown.

As a matter of basic science, the finding strengthens the evidence of a striking parallel between the skin's response to UVA light and the way the eye detects light.

"Its exciting because it confirms this phototransduction pathway is similar to those found in the eye. It consists of a light-sensitive receptor, molecular signaling cascade, and an ion channel," Oancea said. "The involvement of an ion channel makes this pathway a lot more like other phototransduction pathways."

In other parts of the body, TRPA1 has been shown to help detect pungent but benign chemicals, such as those in intensely flavorful foods. Oancea and lead author Nicholas Bellono said the chemical sensitivity of TRPA1 offers the intriguing possibility that it could become a target for experiments to boost melanin production.

"TRPA1 ion channels are involved in the detection of pungent chemicals such as cinnamaldehyde, wasabi, and mustard oil, and we've now found it's important for this melanin response," Bellono said. "There is a possibility that we can pharmacologically alter pigmentation through regulation of this ion channel."

Oancea and Bellono emphasized, however, that people who go out in the sun should always take widely recommended precautions to protect their skin, such as using high-SPF commercial sunscreens or wearing protective hats and clothing.

Finding the channel

From the prior research in Oancea's lab, Bellono knew he was looking for some kind of molecular pathway that would start with a light sensitive receptor and trigger an elevated level of calcium ions in the melanocytes.

It seemed possible that a TRP ion channel would be involved because TRPs are involved in phototransduction elsewhere in the body that lead to an increase in intracellular calcium. There are, however, many types of TRP channels, and the molecular identity of the UVA-activated channel in melanocytes was not apparent. Oancea confessed that she even suspected another as the culprit. But many experiments later, the team hit on TRPA1 and amassed considerable evidence to confirm its vital role.

In one experiment, for example, they treated melanocytes with "antagonist" chemicals known to block TRPA1 activity. They then exposed the cells to UVA light and measured the resulting electrical response. The cells blocked with the antagonists had 80 to 90 percent reduction in current compared to the unhindered cells.

They used a similar technique of specifically blocking TRPA1 activity to show that the ion channel contributes greatly to the presence of calcium ions after UVA exposure compared to unhindered melanocyte cells. They also found melanocytes produce little or no melanin following exposure to UVA when TRPA1 is blocked.

They did not, however, do experiments to see whether adding TRPA1 stimulating substances could increase melanin production.

In addition to Bellono and Oancea, other authors on the paper are Laura Kammel and Anita Zimmerman.

The National Science Foundation, the National Institutes of Health (grant T32-GM077995), and Brown University funded the research.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/97lwapjuqHY/130121161928.htm

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